Check out the official injury report for Sunday's matchup. This was taken from the San Francisco 49ers official website. This information was no where to be found on the Saints official website. Surprise.
San Francisco 49ers
| Name | Position | Injury | Wednesday | Thursday | Friday | Friday Status |
| Jonas Jennings | Tackle | Shoulder | Out | Out | Out | Out |
| Shawntae Spencer | Cornerback | Knee | Out | Out | Out | Out |
| Keith Lewis | Safety | Knee | DNP | DNP | LP | Questionable |
| Michael Lewis | Safety | Knee | DNP | LP | LP | Questionable |
| Bryant Johnson | Receiver | Hamstring | DNP | DNP | LP | Questionable |
| Dashon Goldon | Safety | Knee | LP | LP | LP | Questionable |
| Donald Strickland | Cornerback | Knee | LP | LP | LP | Questionable |
| Frank Gore | Running Back | Coaches Decision | DNP | - | - | |
| Walt Harris | Cornerback | Coaches Decision | DNP | - | - |
New Orleans Saints
| Name | Position | Injury | Wednesday | Thursday | Friday | Friday Status |
| Marques Colston | Receiver | Thumb | DNP | DNP | DNP | OUT |
| Aaron Glenn | Cornerback | Ankle | DNP | DNP | DNP | OUT |
| Randall Gay | Cornerback | Hamstring | DNP | LP | LP | Questionable |
| Mike Karney | Fullback | Ankle | DNP | DNP | DNP | OUT |
| Mark Campbell | Tight End | Hamstring | DNP | LP | LP | Questionable |
| David Patten | Receiver | Groin | DNP | DNP | LP | Questionable |
| Jeremy Shockey | Tight End | Hernia | DNP | DNP | DNP | OUT |
| Troy Evans | Linebacker | Ankle | DNP | DNP | LP | Questionable |
| Aaron Stecker | Running Back | Hamstring | LP | LP | LP | Questionable |
| Jammal Brown | Tackle | Hip | LP | LP | FP | Probable |
| Terrance Copper | Receiver | Hamstring | LP | LP | LP | Questionable |
| Antwan Lake | Defensive tackle | Groin | LP | LP | LP | Questionable |
| Scott Fujita | Linebacker | Knee | LP | LP | FP | Probable |
| Jonathan Goodwin | Center | Hamstring | - | DNP | LP | Questionable |