| Player | Pos. | Status | Date |
| DeMario Pressley | DT | Placed on Injured Reserve | July 27, 2008 |
| Adrian Arrington | WR | Placed on Injured Reserve | August 29, 2008 |
| Hollis Thomas | DT | Placed on Injured Reserve | September 9, 2008 |
| Mark Simoneau | LB | Placed on Injured Reserve | September 12, 2008 |
| Tracy Porter | CB | Placed on Injured Reserve | October 7, 2008 |
| Martin Gramatica | K | Placed on Injured Reserve | October 8, 2008 |
| Charles Grant | DE | Placed on Injured Reserve | November 3, 2008 |
| Mike McKenzie | CB | Placed on Injured Reserve | November 10, 2008 |
| Brian Young | DT | Placed on Injured Reserve | November 15, 2008 |
| Aaron Stecker | RB | Placed on Injured Reserve | November 18, 2008 |
| Mark Campbell | TE | Placed on Injured Reserve | November 19, 2008 |
| Aaron Glenn | CB | Placed on Injured Reserve | November 27, 2008 |
| Kevin Kaesviharn | S | Placed on Injured Reserve | December 4, 2008 |
| Courtney Roby | WR | Placed on Injured Reserve | December 8, 2008 |
| Reggie Bush | RB | Placed on Injured Reserve | December 17, 2008 |
I understand that some of these players aren't on the team anymore or weren't much of a help in 2008 but the point is that being forced to deal with this incredible amount of injury in one season makes it damn near impossible to have a sucessful year.