- QB Drew Brees faces his former team (2001-05) for the second time. In the last meeting he passed for 339 yards with 3 TDs for a 121.9 rating.
- Brees has a touchdown pass in 47 consecutive games, tied with Johnny Unitas for the longest streak in NFL history.
- RB Darren Sproles also faces his former team (2005-10) for the first time.
- Sproles was a 4th round pick (130th overall) by San Diego in 2005 and had 6,469 kick return yards, 1,400 reception yards, 1,154 rush yards and 935 punt return yards as a Charger.
- Since 2011, Sproles leads all NFL RBs with 109 receptions.
- WR Marques Colston has 9 touchdowns in the past ten games vs. AFC opponents, including four touchdowns in the past three.
- WR Lance Moore had 6 catches for 90 yards and a touchdown in his last meeting with the Chargers.
- TE Jimmy Graham has a touchdown in six of his past seven games.